New Solutions for the Heart by Bruno K. K. Podesser & David J. J. Chambers

Author:Bruno K. K. Podesser & David J. J. Chambers
Language: eng
Format: epub
Publisher: Springer Vienna, Vienna

9.2.1 NO Mediated Effects

Produced by endothelial cells, NO is responsible for the following actions:Vasodilatation (Ignarro et al. 1987)

Inhibition of platelet aggregation (Azuma et al. 1986; Kalinowski et al. 2002; Radomski et al. 1987)

Reduction of oxygen consumption (Recchia et al. 1999; Loke et al. 1999)

Lusitropy (an increase in cardiac compliance) (Paulus and Shah 1999) and therefore

A direct or indirect mediated increase in myocardial contractility (Kanai et al. 1997; Brady et al. 1993)

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